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Glyburide Outperformed Metformin in Treating Women with Gestational Diabetes

• Glycemic Control
• Just like Vytorin

Glycemic Control

Laverne Miller, CMH Hicksville, 15 Jan 2010 6:06 PM EST

Competing interests: None declared

UKPDS, VA Study, now this small one. Glycemic control does NOT seem to matter. Metformin had better (or at least equal) outcomes of the neonates. (Isn't that the whole purpose of glycemic control???) So how could you conclude that glyburide is better?

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Just like Vytorin

Neal F Devitt, La Familia Medical Center, 25 Jan 2010 2:11 PM EST

Competing interests: None declared

While the authors qualify their conclusions, this paper is hyped as showing that glyburide outperforms metformin in the treatment of gestational diabetes. Aside from the overemphasis on markers instead of clinical outcomes, the study also joins the legions of papers published in the ob/gyn journals with a pitifully small number of patients. A number this small should exclude papers from publication.

Meformin outperformed glyburide in clinical outcomes.The lower weight of newborns in the metformin group should overshadow all else in the attention given this study. Excess newborn weight has been associated with increased risk of diabetes, obesity and cardiovascular disease later in life. Any study of treatments for gestational diabetes should model itself on studies of the outcome of premature births and present data on the health of the offspring at 5, 10 and 20 years of age.

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