| Antacids |
| May be combined with alginic acid (foaming agent) |
| Sucralfate |
| Protects mucosa by binding to inflamed tissue; rarely used (not approved for GERD) |
| Promotility agents |
| Of limited utility due to adverse effects |
| H2-receptor antagonists (H2RAs) |
| Inhibit acid secretion by blocking mucosal histamine receptors |
| Agents: cimetidine (Tagamet), ranitidine (Zantac), famotidine (Pepcid), nizatidine (Axid) |
| Proton pump inhibitors (PPIs) |
| Inhibit acid secretion by blocking proton pumps |
| Agents: omeprazole (Prilosec), lansoprazole (Prevacid), rabeprazole (Aciphex), pantoprazole (Protonix), esomeprazole (Nexium) |
