Reassuring Pregnancy Outcomes in Childhood Cancer Survivors
SUMMARY AND COMMENT
November 19, 2009
Ann J. Davis, MD
Offspring of women with childhood cancer histories were not at excess risk for malformations or infant death; preterm birth and cesarean delivery were somewhat more common among childhood cancer survivors.
Reviewing:
Mueller BA et al., Arch Pediatr Adolesc Med 2009 Oct; 163:879
Stability of U.K. Down Syndrome Birth Rate: Age-Related Risks Offset by Antenatal Screening
SUMMARY AND COMMENT
November 19, 2009
Wendy S. Biggs, MD
From 1989 through 2008, better antenatal screening for Down syndrome kept the number of affected live births constant despite a shift toward older maternal age at delivery.
Reviewing:
Morris JK and Alberman E., BMJ 2009 Oct 26; 339:b3794
Breast Tenderness After Starting Menopausal HT: An Ominous Sign?
SUMMARY AND COMMENT
In the WHI trial, HT users with new-onset breast tenderness had higher risk for breast cancer than did HT users without this side effect.
Reviewing:
Crandall CJ et al., Arch Intern Med 2009 Oct 12; 169:1684
BRCA Testing of Women with Ovarian Cancer: Which Strategy Is Best?
SUMMARY AND COMMENT
Testing women of Ashkenazi Jewish ancestry or with family histories of breast or ovarian cancer was projected to be cost-effective for lowering subsequent cancer rates among first-degree relatives.
Reviewing:
Kwon JS et al., J Clin Oncol 2009 Oct 19
For Detecting CIN, Cytology Method Might Not Matter
SUMMARY AND COMMENT
November 19, 2009
Wendy S. Biggs, MD
Liquid-based cytology was as sensitive and specific as conventional Pap tests.
Reviewing:
Siebers AG et al., JAMA 2009 Oct 28; 302:1757
Schiffman M and Solomon D., JAMA 2009 Oct 28; 302:1809
Intravenous Bisphosphonate Therapy for Postmenopausal Women with Low Bone Mass
SUMMARY AND COMMENT
IV zoledronic acid prevented bone loss.
Reviewing:
McClung M et al., Obstet Gynecol 2009 Nov; 114:999
Breast Cancer Screening: Who, When, and How?
CLINICAL PRACTICE GUIDELINE WATCH
New USPSTF guidelines narrow the proposed age range for screening mammography and recommend biennial screening.
Reviewing:
U.S. Preventive Services Task Force., Ann Intern Med 2009 Nov 17; 151:716
Mandelblatt JS et al. for the Breast Cancer Working Group of the Cancer Intervention and Surveillance Modeling Network (CISNET)., Ann Intern Med 2009 Nov 17; 151:738
Kerlikowske K., Ann Intern Med 2009 Nov 17; 151:750
Contraception for Women Who Receive Anticoagulant Therapy for Venous Thrombosis
PRACTICE WATCH
The levonorgestrel IUD and injectable contraception are safe and effective options with noncontraceptive benefits.
Reviewing:
Culwell KR and Curtis KM., Contraception 2009 Oct; 80:337
When Biology Meets Personal Choices
SUMMARY AND COMMENT
November 12, 2009
Anna Wald, MD, MPH
Risks for ischemic stroke and myocardial infarction were substantially higher in women with lupus anticoagulant who smoked or used oral contraceptives.
Reviewing:
Urbanus RT et al., Lancet Neurol 2009 Nov; 8:998
Vaginal Danazol for Abnormal Uterine Bleeding
SUMMARY AND COMMENT
Danazol shortened duration and diminished severity of menstrual bleeding with minimal side effects.
Reviewing:
Luisi S et al., Fertil Steril 2009 Oct; 92:1351